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This calculator is provided as a reference tool for research purposes only. Always follow your institution’s safety protocols when handling research compounds.
Melanotan II 10mg is a research peptide commonly studied in melanocortin receptor research, pigmentation biology, MC pathway signalling and broader neuroendocrine research models.
Melanotan II, also written as MT-II or Melanotan 2, is a synthetic analogue of alpha-melanocyte-stimulating hormone, often shortened to alpha-MSH. Unlike Melanotan I, which is usually discussed as more MC1R-focused, Melanotan II is commonly studied as a broader melanocortin receptor agonist. Research literature describes MTII as a potent non-selective melanocortin ligand with agonist activity at MC1R, MC3R, MC4R and MC5R.
This product is supplied for laboratory research use only. It is not a medicine, tanning product, cosmetic product, supplement, therapeutic product or injectable product for human use.
| Product Detail | Information |
|---|---|
| Product name | Melanotan II |
| Common research names | MT-II, MT2, Melanotan 2 |
| Size | 10mg |
| Product type | Research peptide |
| Research category | Melanocortin Agonists / Pigmentation Research |
| Common research interest | Melanocortin receptor signalling, pigmentation biology, MC pathway research |
| Peptide type | Synthetic cyclic heptapeptide alpha-MSH analogue |
| Form | Lyophilised powder |
| Intended use | Laboratory research only |
| Human use | Not for human consumption, administration, tanning or injection |
| Documentation | Certificate of Analysis should be checked before use |
| Component | Research Class | General Research Role |
| Melanotan II | Synthetic melanocortin peptide analogue | Studied in relation to melanocortin receptor signalling |
| Alpha-MSH analogue structure | Modified melanocyte-stimulating hormone analogue | Used in research models involving pigmentation and neuroendocrine signalling |
| Cyclic heptapeptide structure | Seven-amino-acid cyclic peptide format | Associated with receptor binding and peptide stability research |
| Molecular formula | C50H69N15O9 | Listed in PubChem for Melanotan II |
| Lyophilised peptide preparation | Freeze-dried peptide format | Supports stability before reconstitution when stored correctly |
PubChem lists Melanotan II with the molecular formula C50H69N15O9. Product identity, purity and batch information should always be confirmed through supplier documentation and the Certificate of Analysis.
Melanotan II is studied as a melanocortin receptor agonist. The melanocortin receptor family is involved in several biological research areas, including pigmentation signalling, energy balance models, appetite-related pathways, neuroendocrine regulation and sexual behaviour research models.
In pigmentation research, MC1R is the main receptor pathway commonly discussed because it is involved in melanocyte activity and melanin-related signalling. In broader neuroendocrine research, MC3R and MC4R are often discussed in relation to appetite, energy balance and central nervous system pathway models.
This broader receptor activity is one of the key differences between Melanotan II and Melanotan I. Melanotan II should not be described simply as a tanning peptide. For safer website wording, it should be positioned as a melanocortin receptor research peptide studied across multiple MC receptor pathways.
| Research Area | Melanotan II |
| Main research category | Melanocortin receptor research |
| Common receptor focus | MC1R, MC3R, MC4R and MC5R |
| Peptide family | Alpha-MSH analogue |
| Pigmentation pathway interest | Melanin and melanocyte signalling research |
| Neuroendocrine interest | Central melanocortin pathway research |
| Compared with Melanotan I | Broader melanocortin receptor activity |
| Product limitation | Research use only, not approved for general human use |
| Feature | Melanotan I | Melanotan II |
| Also known as | Afamelanotide / MT-I | MT-II / MT2 / Melanotan 2 |
| Structure | Linear alpha-MSH analogue | Cyclic alpha-MSH analogue |
| Main research focus | MC1R and pigmentation pathway research | Broader melanocortin receptor research |
| Receptor discussion | More MC1R-focused | Commonly discussed across MC1R, MC3R, MC4R and MC5R |
| Common research interest | Eumelanin, photobiology and pigmentation models | Pigmentation, neuroendocrine signalling and melanocortin pathway models |
| Human-use product claim | Not appropriate for this research product | Not appropriate for this research product |
| Common Online Claim | Safer Research-Use Wording |
| Tanning | Studied in relation to melanocortin receptor signalling and pigmentation models |
| Skin darkening | Studied in relation to melanin, melanocyte and MC1R pathway research |
| Sunless tanning | Not an approved or appropriate product claim |
| Appetite suppression | Studied only as part of central melanocortin pathway research models |
| Libido enhancement | Studied only as part of broader melanocortin neuroendocrine pathway research |
| Weight loss | Not an approved or appropriate product claim |
| Cosmetic enhancement | Not an approved or appropriate product claim |
| Anti-ageing | Not an approved or appropriate product claim |
Melanotan II 10mg is not intended to diagnose, treat, cure or prevent any disease. It is not supplied for tanning, sunless tanning, skin darkening, cosmetic enhancement, libido enhancement, appetite control, weight loss, anti-ageing, body enhancement, performance enhancement or general wellness use.
All information on this page is provided for laboratory research and product handling context only.
There is no universal recommended dilution for Melanotan II 10mg. Dilution depends on the research protocol, required working concentration, assay design, solvent compatibility, storage method and validated laboratory procedure.
For research concentration planning only, the basic formula is:
Total peptide amount divided by diluent volume equals final concentration.
| Diluent Added to 10mg Vial | Final Concentration |
| 1mL | 10mg/mL |
| 2mL | 5mg/mL |
| 2.5mL | 4mg/mL |
| 3mL | 3.33mg/mL |
| 4mL | 2.5mg/mL |
| 5mL | 2mg/mL |
| 10mL | 1mg/mL |
These are research concentration examples only. They are not human dosing instructions and must not be used to calculate injection quantities.
Before handling Melanotan II 10mg in a laboratory setting, make sure all materials, documentation and clean handling conditions are prepared.
| Item | Purpose |
| Product vial | Contains lyophilised Melanotan II peptide |
| Certificate of Analysis | Confirms batch-level testing information |
| Suitable research-grade diluent | Used to prepare a working research solution |
| Sterile lab consumables | Helps reduce contamination risk |
| Personal protective equipment | Gloves, lab coat and eye protection |
| Alcohol wipes or approved disinfectant | Used for surface and vial-top preparation |
| Laboratory labels | Records concentration, date, batch and handler details |
| Cold storage access | Supports correct storage after preparation |
| Disposal container | Used for compliant laboratory waste disposal |
The following is a general laboratory handling framework only. Always follow the product Certificate of Analysis, supplier documentation, SDS, institutional procedures and validated research protocol.
Check the product label, batch number, Certificate of Analysis and storage requirements before handling the vial.
Use a clean laboratory workspace. Wear appropriate PPE and disinfect the bench surface, vial top and any required equipment.
If the vial has been stored cold, allow it to equilibrate according to laboratory procedure before opening or reconstitution. Avoid condensation entering the vial.
Add the selected research-grade diluent slowly down the inside wall of the vial. Avoid forceful spraying directly onto the lyophilised powder.
Gently swirl or roll the vial until the powder is dissolved. Avoid aggressive shaking, unnecessary vortexing or foaming unless a validated protocol specifically allows it.
Check the solution for cloudiness, visible particles, unusual colour changes or undissolved material. If anything appears abnormal, quarantine the vial and check supplier documentation.
Label the vial or aliquots with the product name, concentration, diluent used, date prepared, batch number and researcher initials.
Place the reconstituted solution into the required storage condition as soon as possible. Avoid unnecessary warming, cooling or repeated freeze-thaw cycles.
Some lyophilised peptide products may take time to fully hydrate. Dissolution should always be handled gently and according to laboratory protocol.
| Issue | What It May Indicate | Safer Response |
| Powder clinging to vial wall | Static or lyophilisation residue | Allow more contact time with diluent |
| Small particles remain | Incomplete hydration | Continue gentle swirling |
| Cloudy solution | Possible incompatibility or contamination | Stop and check documentation |
| Foaming | Too much agitation | Let the solution settle and avoid shaking |
| Colour change | Possible degradation or contamination | Do not continue without supplier guidance |
| Storage Factor | Guidance |
| Product form | Lyophilised powder |
| Storage condition | Follow supplier label and Certificate of Analysis |
| Light exposure | Protect from unnecessary light exposure |
| Moisture exposure | Keep sealed until use |
| Temperature changes | Avoid repeated temperature cycling |
| Handling | Minimise unnecessary opening or vial puncture |
| Storage Factor | Guidance |
| Storage condition | Follow validated research protocol |
| Labelling | Record concentration, date, diluent and batch number |
| Freeze-thaw cycles | Avoid repeated freeze-thaw exposure |
| Aliquoting | Use small research aliquots where appropriate |
| Contamination control | Use clean laboratory technique |
| Light exposure | Protect from unnecessary light exposure where required |
| Disposal | Dispose according to laboratory waste procedures |
Peptides may be sensitive to temperature, light, pH, agitation and contamination. Storage conditions should be confirmed through supplier documentation or the laboratory’s validated method.
This page does not provide human dosing, injection instructions, injection schedules or administration guidance.
Melanotan II 10mg is not supplied for human or animal administration. It is a laboratory research-use product only.
The TGA warns that unapproved peptide products promoted online may be poorly labelled, contaminated or unsafe, and that they have not been assessed for safety, quality or effectiveness.
For research settings, any measured aliquots should be prepared according to the concentration required by the approved research protocol. All calculations should be checked, documented and traceable.
| Planning Item | What to Record |
| Final concentration | Total peptide amount and diluent volume |
| Working solution | Concentration used in the research protocol |
| Aliquot volume | Volume transferred into each labelled lab tube |
| Batch details | Product batch, CoA and preparation date |
| Storage location | Fridge, freezer or other controlled storage area |
| Handler details | Researcher name or initials |
| Preparation date | Date and time of reconstitution |
| Disposal date | When the aliquot should no longer be used |
Correct handling is important for research consistency, contamination control and product traceability. Most mistakes occur when products are not labelled clearly, concentration calculations are not recorded or storage conditions are not followed.
Because Melanotan II is widely misrepresented online as a tanning product, product pages should avoid language that could be interpreted as encouraging cosmetic or self-use.
| Always | Why It Matters |
| Check the Certificate of Analysis | Confirms batch-level information |
| Use PPE | Reduces contamination and exposure risk |
| Label every vial and aliquot | Prevents mix-ups |
| Record concentration calculations | Supports traceability |
| Use clean laboratory technique | Reduces contamination risk |
| Follow institutional protocols | Keeps handling consistent and auditable |
| Store according to documentation | Helps protect peptide integrity |
| Dispose of lab waste correctly | Supports safety and compliance |
| Use research-use wording only | Reduces misleading human-use interpretation |
| Never | Why It Is Risky |
| Never use for self-injection | Product is research use only |
| Never sell or promote as a tanning product | Creates human-use and compliance risk |
| Never make sunless tanning claims | Not an approved or appropriate product claim |
| Never make libido or appetite claims | Not an approved or appropriate product claim |
| Never make cosmetic enhancement claims | Not an approved or appropriate product claim |
| Never assume purity without CoA | Batch quality must be documented |
| Never use a damaged or unlabelled vial | Identity and sterility may be uncertain |
| Never shake aggressively | May affect peptide integrity |
| Never use random solvents | May damage the peptide or alter research results |
| Never leave reconstituted product unlabelled | Creates traceability risk |
| Never rely on social media protocols | They may be inaccurate, unsafe or non-compliant |
The table below is for concentration planning only. It does not represent dosage, injection quantity or recommended administration.
| Total Vial Amount | Diluent Volume | Final Concentration |
| 10mg | 1mL | 10mg/mL |
| 10mg | 2mL | 5mg/mL |
| 10mg | 2.5mL | 4mg/mL |
| 10mg | 3mL | 3.33mg/mL |
| 10mg | 4mL | 2.5mg/mL |
| 10mg | 5mL | 2mg/mL |
| 10mg | 10mL | 1mg/mL |
If a researcher adds 2mL of suitable research-grade diluent to a 10mg vial, the resulting concentration is 5mg/mL.
This calculation is for research concentration planning only. It is not a human or animal dosing example.
Melanotan II is a synthetic cyclic alpha-MSH analogue studied in melanocortin receptor research. It is commonly discussed in relation to MC1R, MC3R, MC4R and MC5R pathway activity.
No. Melanotan I and Melanotan II are different melanocortin research peptides. Melanotan I is generally discussed as more MC1R-focused, while Melanotan II is commonly discussed as having broader melanocortin receptor activity.
No. The TGA states that melanotan products are not approved for sale or use as tanning agents in Australia.
No. This product should not be promoted or used for tanning, sunless tanning, skin darkening, cosmetic enhancement or any human-use purpose.
Melanotan II interacts with broader melanocortin receptor pathways beyond MC1R, including receptors involved in central nervous system research. This should only be discussed as research context and must not be promoted as a human-use benefit.
A Certificate of Analysis provides batch-level testing information. It helps researchers verify product identity, purity and quality documentation before use in a research setting.
| Resource | Why It Is Useful |
| PubChem Melanotan II compound profile | Useful background on Melanotan II molecular formula and compound identity. |
| Melanocortin ligand review | Useful background on MTII as a non-selective melanocortin ligand with MC1R, MC3R, MC4R and MC5R activity. |
| TGA melanotan warning | Important Australian regulatory context explaining that melanotan products are not approved for tanning use in Australia. |
Research Use Only: Melanotan II 10mg is supplied strictly for laboratory research purposes. It is not intended for human or animal consumption, injection, therapeutic use, cosmetic use, diagnostic use, tanning, sunless tanning, skin darkening, libido enhancement, appetite control, weight loss, anti-ageing, body enhancement or performance enhancement. Information on this page is provided for research education and product handling context only. Always follow applicable laws, institutional procedures, supplier documentation and qualified laboratory protocols.
