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This calculator is provided as a reference tool for research purposes only. Always follow your institution’s safety protocols when handling research compounds.
Melanotan I 10mg is a research peptide commonly studied in melanocortin receptor research, pigmentation biology, photobiology and melanin pathway studies.
Melanotan I is also known as afamelanotide. It is a synthetic analogue of alpha-melanocyte-stimulating hormone, often shortened to alpha-MSH. In research settings, it is mainly examined for its relationship with melanocortin-1 receptor activity and eumelanin production pathways. PubChem describes afamelanotide as a melanocortin-1 receptor agonist that stimulates melanin production.
This product is supplied for laboratory research use only. It is not a medicine, tanning product, cosmetic product, therapeutic product, supplement or injectable product for human use.
| Product Detail | Information |
|---|---|
| Product name | Melanotan I |
| Common research name | MT-I |
| Also known as | Afamelanotide |
| Size | 10mg |
| Product type | Research peptide |
| Research category | Melanocortin Agonists / Pigmentation Research |
| Common research interest | MC1R signalling, melanin pathway research, photobiology |
| Form | Lyophilised powder |
| Intended use | Laboratory research only |
| Human use | Not for human consumption, administration, tanning or injection |
| Documentation | Certificate of Analysis should be checked before use |
| Component | Research Class | General Research Role |
| Melanotan I | Synthetic melanocortin peptide analogue | Studied in relation to MC1R signalling and pigmentation pathway research |
| Afamelanotide | Alpha-MSH analogue | Common research and pharmaceutical name associated with Melanotan I |
| Melanocortin receptor agonist activity | MC1R-focused pathway activity | Studied for its relationship with eumelanin production |
| Lyophilised peptide preparation | Freeze-dried peptide format | Supports stability before reconstitution when stored correctly |
PubChem lists Melanotan I with the molecular formula C78H111N21O19. The product identity, purity and batch information should always be confirmed through supplier documentation and the Certificate of Analysis.
Melanotan I is studied as a melanocortin receptor agonist, with strong research interest around the melanocortin-1 receptor, also known as MC1R.
MC1R is involved in melanocyte signalling and melanin production pathways. In simplified research terms, Melanotan I is examined for how it may interact with MC1R and influence eumelanin-related pigmentation models.
Melanotan I is different from Melanotan II. Melanotan I is generally discussed as more MC1R-focused, while Melanotan II is commonly discussed as having broader melanocortin receptor activity. For product pages, this difference should be framed carefully as research context only, not as a safety or human-use claim.
| Research Area | Melanotan I |
| Main research category | Melanocortin receptor research |
| Common receptor focus | MC1R |
| Peptide family | Alpha-MSH analogue |
| Pigmentation pathway interest | Melanin and eumelanin signalling research |
| Photobiology interest | Skin pigmentation and light-response research models |
| Compared with Melanotan II | Often discussed as more MC1R-focused |
| Product limitation | Research use only, not approved for general human use |
| Feature | Melanotan I | Melanotan II |
| Also known as | Afamelanotide / MT-I | MT-II |
| Research focus | MC1R and pigmentation pathway research | Broader melanocortin receptor research |
| Common research interest | Eumelanin, photobiology and pigmentation models | Pigmentation, melanocortin signalling and broader receptor activity |
| Human-use product claim | Not appropriate for this research product | Not appropriate for research products |
| Website positioning | Melanocortin and pigmentation research peptide | Melanocortin agonist research peptide |
| Common Online Claim | Safer Research-Use Wording |
| Tanning | Studied in relation to melanocortin receptor signalling and pigmentation models |
| Skin darkening | Studied in relation to melanin and eumelanin pathway research |
| Sun protection | Studied within photobiology and pigmentation response research |
| Anti-ageing | Not an approved or appropriate product claim |
| Cosmetic enhancement | Not an approved or appropriate product claim |
| Melanin support | Studied in melanocyte and MC1R pathway research |
| Skin health | Should be framed only as pigmentation and photobiology research context |
Melanotan I 10mg is not intended to diagnose, treat, cure or prevent any disease. It is not supplied for tanning, sun protection, skin darkening, cosmetic enhancement, anti-ageing, body enhancement, performance enhancement or general wellness use.
All information on this page is provided for laboratory research and product handling context only.
There is no universal recommended dilution for Melanotan I 10mg. Dilution depends on the research protocol, required working concentration, assay design, solvent compatibility, storage method and validated laboratory procedure.
For research concentration planning only, the basic formula is:
Total peptide amount divided by diluent volume equals final concentration.
| Diluent Added to 10mg Vial | Final Concentration |
| 1mL | 10mg/mL |
| 2mL | 5mg/mL |
| 2.5mL | 4mg/mL |
| 3mL | 3.33mg/mL |
| 4mL | 2.5mg/mL |
| 5mL | 2mg/mL |
| 10mL | 1mg/mL |
These are research concentration examples only. They are not human dosing instructions and must not be used to calculate injection quantities.
Before handling Melanotan I 10mg in a laboratory setting, make sure all materials, documentation and clean handling conditions are prepared.
| Item | Purpose |
| Product vial | Contains lyophilised Melanotan I peptide |
| Certificate of Analysis | Confirms batch-level testing information |
| Suitable research-grade diluent | Used to prepare a working research solution |
| Sterile lab consumables | Helps reduce contamination risk |
| Personal protective equipment | Gloves, lab coat and eye protection |
| Alcohol wipes or approved disinfectant | Used for surface and vial-top preparation |
| Laboratory labels | Records concentration, date, batch and handler details |
| Cold storage access | Supports correct storage after preparation |
| Disposal container | Used for compliant laboratory waste disposal |
The following is a general laboratory handling framework only. Always follow the product Certificate of Analysis, supplier documentation, SDS, institutional procedures and validated research protocol.
Check the product label, batch number, Certificate of Analysis and storage requirements before handling the vial.
Use a clean laboratory workspace. Wear appropriate PPE and disinfect the bench surface, vial top and any required equipment.
If the vial has been stored cold, allow it to equilibrate according to laboratory procedure before opening or reconstitution. Avoid condensation entering the vial.
Add the selected research-grade diluent slowly down the inside wall of the vial. Avoid forceful spraying directly onto the lyophilised powder.
Gently swirl or roll the vial until the powder is dissolved. Avoid aggressive shaking, unnecessary vortexing or foaming unless a validated protocol specifically allows it.
Check the solution for cloudiness, visible particles, unusual colour changes or undissolved material. If anything appears abnormal, quarantine the vial and check supplier documentation.
Label the vial or aliquots with the product name, concentration, diluent used, date prepared, batch number and researcher initials.
Place the reconstituted solution into the required storage condition as soon as possible. Avoid unnecessary warming, cooling or repeated freeze-thaw cycles.
Some lyophilised peptide products may take time to fully hydrate. Dissolution should always be handled gently and according to laboratory protocol.
| Issue | What It May Indicate | Safer Response |
| Powder clinging to vial wall | Static or lyophilisation residue | Allow more contact time with diluent |
| Small particles remain | Incomplete hydration | Continue gentle swirling |
| Cloudy solution | Possible incompatibility or contamination | Stop and check documentation |
| Foaming | Too much agitation | Let the solution settle and avoid shaking |
| Colour change | Possible degradation or contamination | Do not continue without supplier guidance |
| Storage Factor | Guidance |
| Product form | Lyophilised powder |
| Storage condition | Follow supplier label and Certificate of Analysis |
| Light exposure | Protect from unnecessary light exposure |
| Moisture exposure | Keep sealed until use |
| Temperature changes | Avoid repeated temperature cycling |
| Handling | Minimise unnecessary opening or vial puncture |
| Storage Factor | Guidance |
| Storage condition | Follow validated research protocol |
| Labelling | Record concentration, date, diluent and batch number |
| Freeze-thaw cycles | Avoid repeated freeze-thaw exposure |
| Aliquoting | Use small research aliquots where appropriate |
| Contamination control | Use clean laboratory technique |
| Light exposure | Protect from unnecessary light exposure where required |
| Disposal | Dispose according to laboratory waste procedures |
Peptides may be sensitive to temperature, light, pH, agitation and contamination. Storage conditions should be confirmed through supplier documentation or the laboratory’s validated method.
This page does not provide human dosing, injection instructions, injection schedules or administration guidance.
Melanotan I 10mg is not supplied for human or animal administration. It is a laboratory research-use product only.
The TGA warns that unapproved peptide products promoted online may be poorly labelled and may not have been assessed for safety, quality or effectiveness. The TGA also notes that unapproved peptide products often supplied in injectable form can raise serious regulatory and public health risks.
For research settings, any measured aliquots should be prepared according to the concentration required by the approved research protocol. All calculations should be checked, documented and traceable.
| Planning Item | What to Record |
| Final concentration | Total peptide amount and diluent volume |
| Working solution | Concentration used in the research protocol |
| Aliquot volume | Volume transferred into each labelled lab tube |
| Batch details | Product batch, CoA and preparation date |
| Storage location | Fridge, freezer or other controlled storage area |
| Handler details | Researcher name or initials |
| Preparation date | Date and time of reconstitution |
| Disposal date | When the aliquot should no longer be used |
Correct handling is important for research consistency, contamination control and product traceability. Most mistakes occur when products are not labelled clearly, concentration calculations are not recorded or storage conditions are not followed.
| Always | Why It Matters |
| Check the Certificate of Analysis | Confirms batch-level information |
| Use PPE | Reduces contamination and exposure risk |
| Label every vial and aliquot | Prevents mix-ups |
| Record concentration calculations | Supports traceability |
| Use clean laboratory technique | Reduces contamination risk |
| Follow institutional protocols | Keeps handling consistent and auditable |
| Store according to documentation | Helps protect peptide integrity |
| Dispose of lab waste correctly | Supports safety and compliance |
| Never | Why It Is Risky |
| Never use for self-injection | Product is research use only |
| Never sell or promote as a tanning product | Creates human-use and compliance risk |
| Never make sun-protection claims | Not an approved or appropriate product claim |
| Never make cosmetic enhancement claims | Not an approved or appropriate product claim |
| Never assume purity without CoA | Batch quality must be documented |
| Never use a damaged or unlabelled vial | Identity and sterility may be uncertain |
| Never shake aggressively | May affect peptide integrity |
| Never use random solvents | May damage the peptide or alter research results |
| Never leave reconstituted product unlabelled | Creates traceability risk |
| Never rely on social media protocols | They may be inaccurate, unsafe or non-compliant |
The table below is for concentration planning only. It does not represent dosage, injection quantity or recommended administration.
| Total Vial Amount | Diluent Volume | Final Concentration |
| 10mg | 1mL | 10mg/mL |
| 10mg | 2mL | 5mg/mL |
| 10mg | 2.5mL | 4mg/mL |
| 10mg | 3mL | 3.33mg/mL |
| 10mg | 4mL | 2.5mg/mL |
| 10mg | 5mL | 2mg/mL |
| 10mg | 10mL | 1mg/mL |
If a researcher adds 2mL of suitable research-grade diluent to a 10mg vial, the resulting concentration is 5mg/mL.
This calculation is for research concentration planning only. It is not a human or animal dosing example.
Melanotan I is a synthetic alpha-MSH analogue also known as afamelanotide. It is studied in relation to melanocortin receptor signalling, especially MC1R and pigmentation pathway research.
Melanotan I is commonly associated with afamelanotide. However, a research peptide vial should not be treated as equivalent to an approved pharmaceutical product. Product identity, dosage form, quality and approved use all matter.
No. Melanotan I and Melanotan II are different melanocortin research peptides. Melanotan I is generally discussed as more MC1R-focused, while Melanotan II is commonly associated with broader melanocortin receptor activity.
No. This research product is not approved or supplied for tanning, skin darkening, cosmetic enhancement or sun protection.
A specific registered medicine, Scenesse, contains afamelanotide acetate and is approved in Australia for prevention of phototoxicity in adult patients with erythropoietic protoporphyria. This does not make research-use Melanotan I vials approved for human use.
A Certificate of Analysis provides batch-level testing information. It helps researchers verify product identity, purity and quality documentation before use in a research setting.
| Resource | Why It Is Useful |
| PubChem Afamelanotide profile | Useful background on afamelanotide identity, MC1R agonist description and compound data. |
| PubChem Melanotan I profile | Useful background on Melanotan I molecular formula and compound identity. |
| TGA Scenesse decision summary | Explains the specific Australian approval for Scenesse in adult erythropoietic protoporphyria. |
Research Use Only: Melanotan I 10mg is supplied strictly for laboratory research purposes. It is not intended for human or animal consumption, injection, therapeutic use, cosmetic use, diagnostic use, tanning, sun protection, skin darkening, anti-ageing, body enhancement or performance enhancement. Information on this page is provided for research education and product handling context only. Always follow applicable laws, institutional procedures, supplier documentation and qualified laboratory protocols.
