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This calculator is provided as a reference tool for research purposes only. Always follow your institution’s safety protocols when handling research compounds.
MOTS-C 40mg is a synthetic research peptide studied in relation to mitochondrial-derived peptide research, cellular energy signalling, AMPK pathway models, metabolic stress response and exercise-adaptation research contexts.
MOTS-C stands for mitochondrial open reading frame of the 12S rRNA type-c. Research literature describes MOTS-C as a peptide encoded by a short open reading frame within the mitochondrial 12S rRNA gene, with research interest around stress response, exercise response and metabolic pathway signalling.
This product is supplied for laboratory research use only. It is not a medicine, supplement, energy product, endurance product, fat loss product, anti-ageing product, longevity product, metabolic treatment or injectable product for human use.
| Product Detail | Information |
|---|---|
| Product name | MOTS-C |
| Full research name | Mitochondrial open reading frame of the 12S rRNA type-c |
| Common research names | MOTS-c, MDP-16, mitochondrial-derived peptide |
| Size | 40mg |
| Product type | Research peptide |
| Research category | Mitochondrial Research / Metabolic Research |
| Common research interest | AMPK signalling, cellular energy metabolism, mitochondrial-derived peptide biology |
| Peptide type | 16-amino-acid mitochondrial-derived peptide |
| Form | Lyophilised powder |
| Intended use | Laboratory research only |
| Human use | Not for human consumption, administration, performance enhancement or injection |
| Documentation | Certificate of Analysis should be checked before use |
| Component | Research Class | General Research Role |
| MOTS-C | Mitochondrial-derived peptide | Studied in relation to metabolic signalling and stress-adaptation pathways |
| 16-amino-acid peptide structure | Short bioactive peptide | Used in research models involving mitochondrial-derived signalling |
| MT-RNR1 / 12S rRNA context | Mitochondrial genome region | MOTS-C is encoded within the mitochondrial 12S rRNA region |
| AMPK pathway interest | Cellular energy pathway | Studied in relation to energy stress and metabolic adaptation |
| Molecular formula | C101H152N28O22S2 | Listed in PubChem for MOTS-C |
| Lyophilised peptide preparation | Freeze-dried peptide format | Supports stability before reconstitution when stored correctly |
PubChem lists MOTS-C with the molecular formula C101H152N28O22S2. Product identity, purity and batch information should always be confirmed through supplier documentation and the Certificate of Analysis.
MOTS-C is studied as a mitochondrial-derived peptide involved in metabolic stress-response signalling. In research models, MOTS-C is commonly examined for its relationship with AMPK activation, cellular energy regulation, glucose metabolism, mitochondrial function and exercise-adaptation pathways.
A review in Journal of Translational Medicine describes MOTS-C as being expressed in response to stress or exercise and translocating to the nucleus, where it can regulate stress-adaptation-related genes. The same review discusses the Folate-AICAR-AMPK pathway as a key mechanism in MOTS-C research.
This should be understood as laboratory, preclinical and translational research context only. It should not be used as a claim that a research-use MOTS-C 40mg vial has proven human benefits.
| Research Area | MOTS-C |
| Main research category | Mitochondrial-derived peptide research |
| Full name | Mitochondrial open reading frame of the 12S rRNA type-c |
| Peptide length | 16 amino acids |
| Genome context | Encoded within mitochondrial 12S rRNA region |
| Common pathway interest | AMPK and cellular energy signalling |
| Metabolic interest | Glucose metabolism, energy homeostasis and stress-adaptation models |
| Exercise research interest | Exercise-adaptation and metabolic stress-response models |
| Evidence limitation | Mostly preclinical, laboratory and early translational research |
| Product limitation | Research use only, not approved for human use |
| Feature | MOTS-C | Other Mitochondrial Research Peptides |
| Research class | Mitochondrial-derived peptide | May include mitochondrial-derived or mitochondria-targeted peptides |
| Main research interest | AMPK, cellular energy and metabolic stress-response signalling | Varies depending on peptide target and structure |
| Genome context | Encoded within mitochondrial 12S rRNA region | Not always mitochondrial genome-encoded |
| Common research model | Metabolic adaptation, glucose metabolism and exercise-response models | Oxidative stress, mitochondrial membrane or cellular protection models |
| Product positioning | Mitochondrial-derived research peptide | Mitochondrial research peptide or compound |
| Human-use claim | Not appropriate for this research product | Not appropriate for research-use products |
| Feature | MOTS-C | AOD-9604 |
| Research class | Mitochondrial-derived peptide | hGH fragment research peptide |
| Main research pathway | AMPK, mitochondrial signalling and cellular energy research | Human growth hormone fragment and lipolysis pathway research |
| Common research interest | Metabolic stress response and energy homeostasis | Adipocyte and lipolysis pathway models |
| Structure | 16-amino-acid mitochondrial-derived peptide | Modified hGH fragment peptide |
| Common SEO risk | Being marketed as energy, endurance or anti-ageing peptide | Being marketed as a fat loss peptide |
| Safer positioning | Mitochondrial-derived peptide research | hGH fragment research peptide |
| Strength | Product Page Positioning |
| MOTS-C 10mg | Lower-strength research vial for protocol-specific concentration planning |
| MOTS-C 20mg | Standard or mid-strength research vial for mitochondrial pathway research |
| MOTS-C 40mg | Higher-strength research vial for larger protocol-specific concentration planning |
MOTS-C strengths should be treated as product variants, not duplicate product pages. If multiple strengths are listed separately, each page should have a strength-specific title, meta description, slug, concentration table and internal links to reduce SEO cannibalisation.
| Common Online Claim | Safer Research-Use Wording |
| More energy | Studied in relation to cellular energy signalling and AMPK pathway research |
| Exercise mimetic | Studied in exercise-adaptation and metabolic stress-response research models |
| Fat loss | Better framed as energy homeostasis and metabolic pathway research |
| Insulin sensitivity | Studied in metabolic research models, not an approved product claim |
| Anti-ageing | Not an approved or appropriate product claim |
| Longevity | Better framed as ageing-related pathway research, not human benefit wording |
| Mitochondrial support | Better framed as mitochondrial-derived peptide signalling research |
| Performance enhancement | Not an approved or appropriate product claim |
MOTS-C 40mg is not intended to diagnose, treat, cure or prevent any disease. It is not supplied for energy enhancement, endurance, exercise replacement, fat loss, weight loss, insulin sensitivity, diabetes management, anti-ageing, longevity, recovery, bodybuilding, metabolic health, performance enhancement or general wellness use.
All information on this page is provided for laboratory research and product handling context only.
There is no universal recommended dilution for MOTS-C 40mg. Dilution depends on the research protocol, required working concentration, assay design, solvent compatibility, storage method and validated laboratory procedure.
For research concentration planning only, the basic formula is:
Total peptide amount divided by diluent volume equals final concentration.
| Diluent Added to 40mg Vial | Final Concentration |
| 1mL | 40mg/mL |
| 2mL | 20mg/mL |
| 4mL | 10mg/mL |
| 5mL | 8mg/mL |
| 8mL | 5mg/mL |
| 10mL | 4mg/mL |
| 20mL | 2mg/mL |
| 40mL | 1mg/mL |
These are research concentration examples only. They are not human dosing instructions and must not be used to calculate injection quantities.
Before handling MOTS-C 40mg in a laboratory setting, make sure all materials, documentation and clean handling conditions are prepared.
| Item | Purpose |
| Product vial | Contains lyophilised MOTS-C peptide |
| Certificate of Analysis | Confirms batch-level testing information |
| Suitable research-grade diluent | Used to prepare a working research solution |
| Sterile lab consumables | Helps reduce contamination risk |
| Personal protective equipment | Gloves, lab coat and eye protection |
| Alcohol wipes or approved disinfectant | Used for surface and vial-top preparation |
| Laboratory labels | Records concentration, date, batch and handler details |
| Cold storage access | Supports correct storage after preparation |
| Disposal container | Used for compliant laboratory waste disposal |
The following is a general laboratory handling framework only. Always follow the product Certificate of Analysis, supplier documentation, SDS, institutional procedures and validated research protocol.
Check the product label, batch number, Certificate of Analysis and storage requirements before handling the vial.
Use a clean laboratory workspace. Wear appropriate PPE and disinfect the bench surface, vial top and any required equipment.
If the vial has been stored cold, allow it to equilibrate according to laboratory procedure before opening or reconstitution. Avoid condensation entering the vial.
Add the selected research-grade diluent slowly down the inside wall of the vial. Avoid forceful spraying directly onto the lyophilised powder.
Gently swirl or roll the vial until the powder is dissolved. Avoid aggressive shaking, unnecessary vortexing or foaming unless a validated protocol specifically allows it.
Check the solution for cloudiness, visible particles, unusual colour changes or undissolved material. If anything appears abnormal, quarantine the vial and check supplier documentation.
Label the vial or aliquots with the product name, concentration, diluent used, date prepared, batch number and researcher initials.
Place the reconstituted solution into the required storage condition as soon as possible. Avoid unnecessary warming, cooling or repeated freeze-thaw cycles.
Some lyophilised peptide products may take time to fully hydrate. Dissolution should always be handled gently and according to laboratory protocol.
| Issue | What It May Indicate | Safer Response |
| Powder clinging to vial wall | Static or lyophilisation residue | Allow more contact time with diluent |
| Small particles remain | Incomplete hydration | Continue gentle swirling |
| Cloudy solution | Possible incompatibility or contamination | Stop and check documentation |
| Foaming | Too much agitation | Let the solution settle and avoid shaking |
| Colour change | Possible degradation or contamination | Do not continue without supplier guidance |
| Storage Factor | Guidance |
| Product form | Lyophilised powder |
| Storage condition | Follow supplier label and Certificate of Analysis |
| Light exposure | Protect from unnecessary light exposure |
| Moisture exposure | Keep sealed until use |
| Temperature changes | Avoid repeated temperature cycling |
| Handling | Minimise unnecessary opening or vial puncture |
| Storage Factor | Guidance |
| Storage condition | Follow validated research protocol |
| Labelling | Record concentration, date, diluent and batch number |
| Freeze-thaw cycles | Avoid repeated freeze-thaw exposure |
| Aliquoting | Use small research aliquots where appropriate |
| Contamination control | Use clean laboratory technique |
| Light exposure | Protect from unnecessary light exposure where required |
| Disposal | Dispose according to laboratory waste procedures |
Peptides may be sensitive to temperature, light, pH, agitation and contamination. Storage conditions should be confirmed through supplier documentation or the laboratory’s validated method.
This page does not provide human dosing, injection instructions, injection schedules or administration guidance.
MOTS-C 40mg is not supplied for human or animal administration. It is a laboratory research-use product only.
For research settings, any measured aliquots should be prepared according to the concentration required by the approved research protocol. All calculations should be checked, documented and traceable.
| Planning Item | What to Record |
| Final concentration | Total peptide amount and diluent volume |
| Working solution | Concentration used in the research protocol |
| Aliquot volume | Volume transferred into each labelled lab tube |
| Batch details | Product batch, CoA and preparation date |
| Storage location | Fridge, freezer or other controlled storage area |
| Handler details | Researcher name or initials |
| Preparation date | Date and time of reconstitution |
| Disposal date | When the aliquot should no longer be used |
| Strength check | Confirmation that the 40mg vial strength matches the approved research protocol |
Correct handling is important for research consistency, contamination control and product traceability. Most mistakes occur when products are not labelled clearly, concentration calculations are not recorded or storage conditions are not followed.
Because MOTS-C is commonly discussed online in relation to mitochondrial support, energy, exercise adaptation and anti-ageing, product pages should avoid wording that could be interpreted as encouraging human performance enhancement, self-injection, longevity use or metabolic treatment.
| Always | Why It Matters |
| Check the Certificate of Analysis | Confirms batch-level information |
| Use PPE | Reduces contamination and exposure risk |
| Label every vial and aliquot | Prevents mix-ups |
| Record concentration calculations | Supports traceability |
| Use clean laboratory technique | Reduces contamination risk |
| Follow institutional protocols | Keeps handling consistent and auditable |
| Store according to documentation | Helps protect peptide integrity |
| Dispose of lab waste correctly | Supports safety and compliance |
| Use research-use wording only | Reduces misleading human-use interpretation |
| Clearly separate research pathways from human benefit claims | Avoids unsafe or misleading product positioning |
| Clearly separate each strength variant | Reduces product confusion and SEO cannibalisation |
| Never | Why It Is Risky |
| Never use for self-injection | Product is research use only |
| Never sell or promote as an energy product | Creates human-use and compliance risk |
| Never make endurance or performance claims | Not an approved or appropriate product claim |
| Never make anti-ageing or longevity claims | Not an approved or appropriate product claim |
| Never describe it as an exercise replacement | Misleading and not appropriate for research-use material |
| Never make diabetes or insulin-sensitivity treatment claims | Not an approved or appropriate product claim |
| Never assume purity without CoA | Batch quality must be documented |
| Never use a damaged or unlabelled vial | Identity and sterility may be uncertain |
| Never shake aggressively | May affect peptide integrity |
| Never use random solvents | May damage the peptide or alter research results |
| Never leave reconstituted product unlabelled | Creates traceability risk |
| Never rely on social media protocols | They may be inaccurate, unsafe or non-compliant |
| Never reuse generic content from another MOTS-C strength without changing the strength-specific details | This can create duplicate content and poor SEO clarity |
The table below is for concentration planning only. It does not represent dosage, injection quantity or recommended administration.
| Total Vial Amount | Diluent Volume | Final Concentration |
| 40mg | 1mL | 40mg/mL |
| 40mg | 2mL | 20mg/mL |
| 40mg | 4mL | 10mg/mL |
| 40mg | 5mL | 8mg/mL |
| 40mg | 8mL | 5mg/mL |
| 40mg | 10mL | 4mg/mL |
| 40mg | 20mL | 2mg/mL |
| 40mg | 40mL | 1mg/mL |
If a researcher adds 8mL of suitable research-grade diluent to a 40mg vial, the resulting concentration is 5mg/mL.
This calculation is for research concentration planning only. It is not a human or animal dosing example.
MOTS-C is a mitochondrial-derived research peptide. Its full name is mitochondrial open reading frame of the 12S rRNA type-c. It is studied in relation to mitochondrial-derived peptide signalling, AMPK pathway research, cellular energy metabolism and metabolic stress-response models.
Yes. MOTS-C is commonly described as a mitochondrial-derived peptide because it is encoded by a short open reading frame within the mitochondrial 12S rRNA region.
MOTS-C is commonly studied in relation to AMPK signalling, cellular energy regulation, glucose metabolism, metabolic stress response and exercise-adaptation research. Reviews describe AMPK-related mechanisms as central to MOTS-C pathway research.
No. This research product is not approved or supplied for energy enhancement, endurance, performance, anti-ageing, longevity, fat loss, metabolic treatment or human use. It should be described only as a laboratory research product.
No. MOTS-C is a mitochondrial-derived peptide studied in AMPK and cellular energy pathway research. AOD-9604 is an hGH fragment research peptide, while Tirzepatide is a dual GIP and GLP-1 receptor agonist research peptide. These products belong to different research classes.
The active research peptide is the same product type, but the total vial content is different. The 40mg vial allows different concentration planning for qualified research settings. It should be treated as a strength variant, not a separate therapeutic claim.
They can be separate pages if each strength has a unique title, meta description, slug, concentration table and internal linking. If the content is mostly identical, a variable product structure may be better for SEO.
A Certificate of Analysis provides batch-level testing information. It helps researchers verify product identity, purity and quality documentation before use in a research setting.
| Resource | Why It Is Useful |
| PubChem MOTS-C compound profile | Useful background on MOTS-C identity and molecular formula. |
| MOTS-C mitochondrial-derived peptide review | Useful background on MOTS-C, AMPK signalling, stress response and metabolic pathway research. |
| MOTS-C 12S rRNA encoding review | Useful background on MOTS-C as a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA region. |
MOTS-C 40mg for qualified laboratory research only. Not for human or veterinary use.
